Fast-Dissolving Protein Nanofibrous Membrane for Dual Drug Oral Delivery

Oral instant membranes can be quickly wetted by the patient’s saliva and dissolved/disintegrated in mouth without need for drinking water chewing, exhibiting great promise patients from children to elderly who have difficulties with swallowing. However, reported oral load release only one single drug, which greatly hinders their potential applications. Herein, we employ a sequential electrospinning approach fabricate dual drug-loaded bilayered gelatin membranes. The results indicate that membrane uniform nanofibrous structure successfully prepared, both hydrophilic model drug hydrophobic embedded into nanofibers. X-ray diffraction verify two drugs are well distributed matrix an amorphous state. Owing excellent solubility large surface area of nanofibers, dissolved 101 s, while completely released 100 s. shows simultaneous loading fast-dissolving delivery